Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice
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چکیده
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Nigrostriatal dynein changes in A53T alpha-synuclein transgenic mice
The accumulation of misfolded a-synuclein is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other alpha-synucleinopathies. However, how alpha-synuclein causes neurodegeneration is unresolved. Several studies have supported the involvement of dynein, the major motor for retrograde axonal transport in alpha-synuclein-dependent neurodegeneration, especially in the nigr...
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ژورنال
عنوان ژورنال: Neurobiology of Aging
سال: 2021
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2021.01.010